Polycopié de bio-informatique pour le cours EMBO sur

Module 6 BIOINFORMATICS Jérome Gouzy and Daniel Kahn Local organiser: Peter Mergaert 1. Gene detection in genomic sequences .............................................................................................................. 3 EuGène : A Eukaryotic Gene finder that combines several sources of evidence.......... 3 2. Protein sequence annotation............................................................................................................................. 4 Homology search........................................... 5 Protein domains and motifs........................... 6 Signal peptides, targeting peptides and transmembrane helices .................................... 7 Links.............................................................................................................................. 7 References..................................................... 7 3. EST clustering and annotation......................... 8 Clustering methodology................................................................................................................................. 8 Difficulties of EST clustering........................ 8 Links.............................................................. 9 References..................................................................................................................... 9 4. Medicago specific resources............................. 9 5. Database ...