Paracétamol - Etude sur les effets secondaires à long terme

ARD Online First, published on March 2, 2015 as 10.1136/annrheumdis-2014-206914 Clinical and epidemiological research Handling editorTore K Kvien ▸Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/ annrheumdis2014206914). For numbered affiliations see end of article. Correspondence to Professor Philip G Conaghan Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds LS7 4SA, UK; p.conaghan@leeds.ac.uk Received 31 October 2014 Revised 4 December 2014 Accepted 13 January 2015 To cite:Roberts E, Delgado Nunes V, Buckner S,et al. Ann Rheum DisPublished Online First: [please include Day Month Year] doi:10.1136/annrheumdis 2014206914 EXTENDED REPORT Paracetamol: not as safe as we thought? A systematic literature review of observational studies 1 2 2 2 Emmert Roberts, Vanessa Delgado Nunes, Sara Buckner, Susan Latchem, 2 2 3 3 4 Margaret Constanti, Paul Miller, Michael Doherty, Weiya Zhang, Fraser Birrell, 5 6 7,8 9 Mark Porcheret, Krysia Dziedzic, Ian Bernstein, Elspeth Wise, 10 Philip G Conaghan ABSTRACT ObjectivesWe conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol. MethodsWe searched Medline and Embase from database inception to 1 May 2013.